This special issue brings together developments in neurological, psychological and social understanding of sense of self and identity in neuropsychological rehabilitation. Following brain injury and in the context of neurological illness, both the individual and their loved ones report changes in personality, sense of self or identity. This issue is intended to be a key resource for clinicians trying to tackle these challenges, as well as researchers interested in the self and identity in clinical populations. New theoretical perspectives on the self, as well as quantitative and qualitative research studies, and clinical and service issues are covered.