Between 200 and 1200 CE Central Mexico was the setting for the formation and disintegration of two states, Teotihuacan and Tula. At their peaks, both urban centers established distant ties throughout Mesoamerica. The nature of their relations has been the focus of analysis and debate for decades. In this study, Peter Jimenez uses the latest advances in world-systems analysis to study interaction networks in West Mexico from the early Classic to Post-classic period. He demonstrates how the archaeological record contains empirical evidence for the impact of global processes on local developments, in detail, in realms, and at spatial scales, which are revealed here for the first time. His examination of West Mexico's relations to the core states of Central Mexico also underscores the critical role that the semi-periphery played in overall world-system configuration and operation in ancient Mesoamerica.