This book constitutes the proceedings of the 1st International Conference on Systems and Information Sciences (ICCIS), held in Manta, Ecuador, from July 27 to 29, 2020, and was jointly organized by Universidad Laica Eloy Alfaro de Manabí “ULEAM”, in collaboration with GDEON. ICCIS aims to bring together systems and information sciences researchers and developers from academia and industry around the world to discuss cutting-edge research. The book covers the following topics:AI, Expert Systems and Big Data AnalyticsCloud, IoT and Distributed ComputingCommunicationsDatabase System and ApplicationFinancial Technologies (FinTech), Economics and Business Engineeringm-Learning and e-LearningSecuritySoftware EngineeringWeb Information Systems and ApplicationsGeneral Track