In thirteen chapters, twenty-four authors share their analyses, concerns, and conclusions in several domains including the: meaning and dynamics of multiculturalism affecting prevention intervention, relative risks and knowledge gaps across ethnic groups, social trends affecting health risks and substance abuse, lessons learned from substance abuse research and prevention, role of the media, promises and limits of the new public health paradigm for assessment, policy development, assurance of preventive services, and social action and empowerment for prevention in partnership with the public.