This book constitutes the refereed proceedings of the 12th IFIP WG 8.9 Working Conference on Research and Practical Issues of Enterprise Information Systems, CONFENIS 2018, held as part of the World Computer Congress, WCC 2018, in Poznan, Poland, in September 2018. The 12 full papers presented in this volume were carefully reviewed and selected from 28 submissions. They were organized in topical sections named: EIS management and case studies; data management and applications for EIS; collaborative and social interaction; and data access, security, and privacy.