In the last decade substantial progress has been scientists and clinicians to intensify their research made in the understanding of prostatic physio- for better diagnostic techniques. Thanks are due to pathology by the application of modern techniques the contributors who prepared their chapters me- and instrumentation in microanatomy, immunol- ticulously. Thanks also are due to Ms. Lori Rust ogy, neurophysiology, pathology, genetics, endo- for her editorial skills, and to Mr. Jeffrey Smith of Martinus Nijhoff for his fine cooperation during crinology, biochemistry, biophysics and surgery. An attempt is made in this volume to coordinate the production of this volume. anatomical, physiological, biochemical, endocri- nological, pharmacological and immunological as- pects of human prostatic carcinoma. It is hoped E.S.E. HAFEZ that this volume will serve as a stimulus to basic Detroit, Michigan PROSTATIC CARCINOMA: BIOLOG Y AND DIAGNOSIS 1. BIOLOGICAL ASPECTS 1. FUNCTIONAL ANATOMY OF THE PROSTATE E. SPRING-M ILLS and A. KRALL I. EMBRYOLOGY into smooth muscle cells and collagen secreting fibroblasts. These cells form the stroma which ensheaths the branching glands and ejaculatory The prostate gland develops from solid. endo- ducts as they pass from the junction of the vas dermal outgrowths of urogenital sinus epithelium deferens and seminal vesicles to the urethra.