Combining narrative history with data-rich social and economic analysis, this new institutional economics study examines the failure of frontier farms in the antebellum Northwest Territory, where legislatively-created imperfect markets and poor surveying resulted in massive investment losses for both individual farmers and the national economy. The history of farming and spatial settlement patterns in the Great Lakes region is described, with specific focus on the State of Michigan viewed through a case study of Midland County. Inter and intra-state differences in soil endowments, public and private promoters of site-specific investment opportunities, time trends in settled populations and the experiences of individual investors are covered in detail.