This book constitutes the thoroughly refereed proceedings of the Second Iberoamerican Conference, KGSWC 2020, held in Mérida, Mexico, in November 2020. Due to the COVID-19 pandemic the conference was held online. The 15 papers presented were carefully reviewed and selected from 45 submissions. The papers cover research and practices in several fields of AI, such as knowledge representation and reasoning, natural language processing/text mining, machine/deep learning, semantic web, and knowledge graphs.