This book is intended for students, academics, authors, and research-oriented professionals to store, organize, and manage their references for research papers, theses, dissertations, journal articles, and other publications. Its purpose is to educate readers about effective use of information technology in reference management - the process of storing, managing, retrieving and citing scientific references. It also provides step-by-step instruction on using EndNote, a popular reference management software. Since the publication of the third edition, substantial changes have taken place in the field of reference management. EndNote has released a new version – EndNote 20. The web-based knowledge databases such as Web of Science Core Collection, Scopus, and Google Scholar are also being used far more frequently. The fourth edition of EndNote 1-2-3 Easy! incorporates updated instructions and screenshots to ensure that the readers continue to find this a user-friendly book providing accurate and reliable information. For first-time users of EndNote 21, this book is a comprehensive and well-illustrated instruction manual for getting started, including detailed instructions on installation, creating reference libraries, and ultimately creating complete and accurate citation-based bibliographies necessary to achieve successful peer reviewed publications. For existing “power users” of current and earlier versions of EndNote, this book provides quick and easy access to a comprehensive compendium of nuanced and advanced features of this powerful software, with an emphasis on providing greater ease and control in coordinating and curating research materials and bibliographies with research collaborators and scientific writing teams.