In this special issue, leading neuroscientists and neurologists present comprehensive review papers and empirical studies on the topic of the neural basis of self-identification. From philosophical definitions to single-case studies, the articles provide the reader with a broad view of the self in contemporary neuroscience. Review papers address the fundamental question of how to define and study the construct of identity. Methods in empirical studies range from socio-linguistic analyses to neuroimaging and diverse patient populations. As a whole, this issue provides a diverse sample of the myriad of ways in which identity is defined and studied in contemporary neuroscience.