The world is changing and Issue 101 is here to ask the burning questions:How did we get here, where are we going, and how can science guide us to make the right choices? Bianca Nogrady charts the way data is helping Australia negotiate its relationship with fire. Clare Watson takes a hard look at Big Pharma and explores alternative drug development initiatives that put people over profit. Up in Arnhem Land David Hancock finds a collaboration between Western science and First Nations knowledge that is restoring country - and rediscovering species. Meanwhile, a kaleidoscope of other science stories crunch the numbers on maths education, navigate the history of vectors, walk both sides of Goyder's Line, and much more. Join us - this issue is an adventure. This is Issue 101 of Cosmos, a quarterly science print magazine, is produced by The Royal Institution of Australia. Cosmos aims to inspire curiosity and make the world of science accessible to everyone.