This book reports on theoretical and practical analyses of the ethical challenges connected to driving automation. It also aims at discussing issues that have arisen from the European Commission 2020 report “Ethics of Connected and Automated Vehicles. Recommendations on Road Safety, Privacy, Fairness, Explainability and Responsibility”. Gathering contributions by philosophers, social scientists, mechanical engineers, and UI designers, the book discusses key ethical concerns relating to responsibility and personal autonomy, privacy, safety, and cybersecurity, as well as explainability and human-machine interaction. On the one hand, it examines these issues from a theoretical, normative point of view. On the other hand, it proposes practical strategies to face the most urgent ethical problems, showing how the integration of ethics and technology can be achieved through design practices. All in all, this book fosters a multidisciplinary approach where philosophy, ethics, and engineering are integrated, rather than just juxtaposed. It is meant to inform and inspire an audience of philosophers of technology, ethicists, engineers, developers, manufacturers, and regulators, among other interested readers.