The Worm is dead, and Luther has expanded his power base to encompass all of San Antonio. He's got Sammy's mother in his basement, a giant army and a bone to pick, and he's gradually losing his mind. In the meantime, Sammy is on the run from multiple bounty hunters as he tries to plan a raid on Luther's Alamo base to bring him down once and for all.
In a world rich with both grit and surrealism, we learn about Luther's past and witness the opening salvo in a war that will determine the future of Mutations.