Bioinformatics of Genome Regulation and Structure covers: -regulatory genomic sequences: databases, knowledge bases, computer analysis, modeling, and recognition; -large-scale genome analysis and functional annotation; -gene structure detection and prediction; -comparative and evolutionary genomics; -computer analysis of genome polymorphism and evolution; computer analysis and modeling of transcription, splicing, and translation; structural computational biology: structure-function organization of genomic DNA, RNA, and proteins; -gene networks, signal transduction pathways, and genetically controlled metabolic pathways: principles of organization, operation, and evolution; -data warehousing, knowledge discovery and data mining; and, -analysis of basic patterns of genome operation, organization, and evolution. The data presented may be used while solving a wide range of problems, both basic and applied, in various directionsof molecular biology, molecular genetics, biotechnology, pharmacogenetics, pharmacology, and adjacent fields of medicine, veterinary, and agrobiology.