This issue of Sleep Medicine Clinics is edited by Drs. Brown and Shahrokh Javaheri and focuses on Advanced PAP Therapies and Non-invasive Ventilation. Article topics include: Current Positive Airway Pressure Device Technology: What’s in the “black box?”; Testing the Performance of Positive Airway Pressure Generators: From Bench to Bedside; Treatment of Obstructive Sleep Apnea: Choosing the Best PAP Device; Treatment of Obstructive Sleep Apnea: Choosing the Best Interface; Treatment of Obstructive Sleep Apnea: Achieving Adherence and Dealing with Complications; Treatment of Hyperventilatory Central Sleep Apnea: Idiopathic, CHF, Cerebrovascular Disease, and High Altitude; Disordered Breathing Due to Chronic Opioid Use: Diverse Manifestations and Their Management; Obesity Hypoventilation Syndrome: Choosing the Appropriate Treatment for a Heterogeneous Disorder; Positive Airway Pressure Treatment in the Patient with Ventilatory Failure due to Neuromuscular Disease; Non-invasive Ventilation in Acute Ventilatory Failure; Domiciliary Non-invasive Ventilation for Chronic Ventilatory Failure; The Future of Positive Airway Pressure Technology.