Valery Ngoy Ndala, the father of scientific pan-Africanism, uses his reflections to highlight the influence of Western paradigms on the decolonization of knowledge in Africa. He proposes innovative solutions to overcome these obstacles. By analyzing institutional challenges and questioning the imaginary of the African elite, his thinking offers a theoretical framework for rethinking the process of knowledge production in the African context. In so doing, he outlines promising future prospects for this new paradigm, crucial for the development of African science and, more broadly, for Africa. This vision has inspired our book, which proves indispensable for all those interested in scientific pan-Africanism and the decolonization of African knowledge, with a view to building a knowledge base that is authentically African, inclusive, independent and contributing to the continent's sustainable development.