Bioinformatics is an interdisciplinary science which involves molecular bi- ogy, molecular chemistry, physics, mathematics, computational sciences, etc. Mostof thebooksonbiomathematicspublishedwithinthepasttenyearshave consistedofcollectionsofstandardbioinformaticsproblemsandinformational methods,andfocus mainly onthe logisticsofimplementing andmakinguse of various websites, databases, software packages and serving platforms. While these types of books do introduce some mathematical and computational methods alongside the software packages, they are lacking in a systematic and professional treatment of the mathematics behind these methods. It is significant in the field of bioinformatics that not only is the amount of data increasing exponentially, but collaboration is also both widening and deepening among biologists, chemists, physicists, mathematicians, and c- puter scientists. The sheer volume of problems and databases requires - searchers to continually develop software packages in order to process the huge amounts of data, utilizing the latest mathematical methods. The - tent of this book is to provide a professional and in-depth treatment of the mathematical topics necessary in the study of bioinformatics.