Earth, 7026: Civilization has been crippled by the Blood Plague. There is no cure, no treatment, and no hope for the infected. Government has long been forgotten. An order of medics known as the Doctors rule over Earth and impose a harsh standard on what remains of human population to prevent further outbreaks. Orphan Ren Grant has been hunted by the Doctors since childhood under the false accusation of being a carrier of the Blood Plague. Ren's hiding place is finally discovered, but not by the Doctors. Rian Sloan and his group of vigilantes discover and kidnap her. Instead of turning her in to the Doctors and receiving their ransom, Sloan and his group take Ren with them on their mysterious journey for one reason: the Watch Ren's mother entrusted to her before dying, the Watch that is the only missing element in Sloan's plan of escaping Earth. What follows is an adventure full of Doctors and plagues, of flaying knives and space travel, of sacrifice and blind trust, of hope restored and love sacrificed.