Transatlantic relations have been among the most crucially important areas for US foreign policy since 1945. For reasons of self-interest and with regard to common transatlantic values and political, economic and security interests, every American Secretary of State to date has dedicated a considerable period of time to America’s relations with Europe. This book assesses the transatlantic policy which America’s most important post-Second World War Secretaries of State pursued. Brief profiles of each Secretary’s political philosophy and his/her policy towards Europe provide insights into the continuities and changes US foreign policy towards Europe has displayed from 1945 to the present.The book provides a synopsis of America’s relations with Europe during the last six decades. It establishes an overview of the crucial problems in American-European relations and indeed in America’s global role. Each chapter embeds an assessment of the respective Secretaries of State within a general survey of American foreign policy during both the Cold War and the post-Cold War world.This book was published as a special issue of the Journal of Transatlantic Studies.