Jake Palmer is attending a wedding in New York, and Fiona Collins has flown in from London to accompany him to the event. The night before the wedding a U.S. Homeland Security Investigations (HSI) special agent meets Palmer in the hotel bar and requests his help. He leaves Palmer a sealed envelope and tells him to review the contents, saying he will be in touch in a few days. Moments later, the agent is gunned down. Palmer decides to return the envelope to HSI but not until after he and Collins open it. Inside they find a cryptic note from the agent and information related to a counterfeit medicine case involving a drug manufactured by the company where Collins works. The next morning, they take the envelope to HSI's New York office, ending Palmer's involvement in the investigation, or so he thinks. Collins returns to London intent on finding more about the counterfeiting of one of their newest medicines. After an unexpected event changes Palmer's perspective, he teams with the HSI special agent now in charge of the case. Together they pursue those behind a global counterfeit medicine and money-laundering operation. As the investigation unfolds, Palmer makes a startling discovery that raises his personal stake in the outcome and reveals the real reason the murdered HSI agent wanted him involved. With those closest to him now in danger and more patients dying from taking a medication that contains almost none of the life-saving ingredients, time is running out.