Set in 1902 New Orleans, Creoles combine voodoo and Catholicism, but they hide it from the priests. Camelia prepares amulets for three friends and a daughter. Each woman has a special need. Some want children, some want love and normalcy in their lives, and Rosalia wants to consummate her marriage, because she wishes to give her husband the love he deserves. The women consider Camelia a wise woman and go to her with their problems. She puts herbs in each amulet according to the needs of the women and tells them to believe in the power of their amulets. They do believe. She wants nothing more than to serve her people. With her unique challenge, each woman goes through disappointment, and some must take a different path in their lives to attain happiness.