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Synapses / Edition 1

Synapses / Edition 1 in Bloomington, MN
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This superb volume summarizes in lucid and authoritative detail our current understanding of the synapse, a term coined by Sherrington approximately 100 years ago. An exemplary introductory chapter delineates the fascinating path that led to the classical conception of the synapse and sets the stage for a series of excellent reviews that define contemporary themes and achievements in synaptic research, particularly those of molecular mechanism, development, and plasticity. From the quantal hypothesis to synaptic regulation of gene expression, this book, in its scope, quality, and coherence, is a definitive summary of one century's work and a challenging roadmap for the next.
(Zach W. Hall, University of California, San Francisco)
This book provides an impressive and authoritative account of the current state of knowledge of synaptic organization and function. The most exciting advances in the field have been captured in a lucid and informative fashion, and the key unresolved issues emerge in clear focus. For anyone interested in obtaining a more sophisticated view of the workings of the basic cellular unit of brain function, this book will serve as an indispensable companion.
(Thomas Jessell, Columbia University)
Synapses, the sites where neurons communicate with other cells, are where most of the drugs known to affect brain function act. The analysis of synaptic function and architecture is central to understanding how the nervous system works and how drug therapies exert their effects. It also has important implications for the study of learning and memory, of neural development, and, more generally, for the clinical disciplines of neurology and psychiatry.
Edited by W. Maxwell Cowan, Thomas C. Südhof, and Charles F. Stevens, this volume provides a comprehensive and authoritative overview of a century of research on synaptic structure and function culminating in the most recent work. Written by leading experts in the field,
Synapses
will be of interest to a broad range of neuroscientists, including those studying the cellular and molecular mechanisms of synaptic transmission, learning and memory, neuronal plasticity, neurotransmitters, and synaptic morphology. It will also be an essential reference for students and biomedical professionals in all areas of neuroscience.
Contents and contributors:
A Brief History of Synapses and Synaptic Transmission
, W. Maxwell Cowan and Eric R. Kandel
The Structure of Synapses
, Pietro De Camilli, Volker Haucke, Kohji Takei, and Enrico Mugnaini
Physiology of Synaptic Transmission and Short-Term Plasticity
, Wade G. Regehr and Charles F. Stevens
Mechanism and Regulation of Neurotransmitter Release
, Thomas C. Südhof and Richard H. Scheller
Synaptic Vesicle Endocytosis
, Pietro De Camilli, Vladimir I. Slepnev, Oleg Shupliakov, and Lennart Brodin
The Synaptic Cleft and Synaptic Cell Adhesion, Thomas C. Südhof
The Postsynaptic Specialization
, Morgan H.-T. Sheng
Signal Transduction in the Postsynaptic Neuron: Activity-Dependent Regulation of Gene Expression
, Michael E. Greenberg and Edward B. Ziff
Synaptic Plasticity: Diverse Targets and Mechanisms for Regulating Synaptic Efficacy
, Robert C. Malenka and Steven A. Siegelbaum
The Mechanisms and Meaning of Long-Term Synaptic Depression in the Mammalian Brain
, Mark F. Bear and David J. Linden
Synaptic Plasticity and Memory
, Paul D. Grimwood, Stephen J. Martin, and Richard G. M. Morris
Synapse Formation and Maturation
, Ann Marie Craig and Jeff W. Lichtman
Neurotrophins and Refinement of Visual Circuitry
, Edward S. Lein and Carla J. Shatz
Novel Neurotransmitters and Their Neuropsychiatric Relevance
, Solomon H. Snyder and Christopher D. Ferris
Synaptic Variability: New Insights from Reconstructions and Monte Carlo Simulations with Mcell
, Joel R. Stiles, Thomas M. Bartol, Miriam M. Salpeter, Edwin E. Salpeter, and Terrence J. Sejnowski
About the Authors:
W. Maxwell Cowan recently retired as vice president and chief scientific officer at the Howard Hughes Medical Institute (HHMI), Chevy Chase, Maryland. Born and raised in South Africa, Dr. Cowan received his D. Phil from Oxford University and served on the faculty at Oxford before moving to the United States. He was affiliated with Washington University, St.Louis, for 15 years before joining the Salk Institute, where he served as Vice President. In 1986, Dr Cowan returned to Washington University to become Provost and Executive Vice Chancellor. He joined the Howard Hughes Medical Institute in 1988. Dr. Cowan is a Fellow of the Royal Society and a Foreign Associate of the National Academy of Sciences.
Thomas C. Südhof is an HHMI investigator and professor of molecular genetics at the University of Texas Southwestern Medical Center at Dallas. He obtained postdoctoral training first with Victor Whittaker at the Max Planck Institute for Biophysical Chemistry, Göttingen, and then with Michael Brown and Joseph Goldstein in Dallas.
Charles F. Stevens is an HHMI investigator at the Salk Institute for Biological Studies and Adjunct Professor of Pharmacology and of Neuroscience at the University of California, San Diego, School of Medicine. Dr. Stevens is a member of the National Academy of Sciences.
(Zach W. Hall, University of California, San Francisco)
This book provides an impressive and authoritative account of the current state of knowledge of synaptic organization and function. The most exciting advances in the field have been captured in a lucid and informative fashion, and the key unresolved issues emerge in clear focus. For anyone interested in obtaining a more sophisticated view of the workings of the basic cellular unit of brain function, this book will serve as an indispensable companion.
(Thomas Jessell, Columbia University)
Synapses, the sites where neurons communicate with other cells, are where most of the drugs known to affect brain function act. The analysis of synaptic function and architecture is central to understanding how the nervous system works and how drug therapies exert their effects. It also has important implications for the study of learning and memory, of neural development, and, more generally, for the clinical disciplines of neurology and psychiatry.
Edited by W. Maxwell Cowan, Thomas C. Südhof, and Charles F. Stevens, this volume provides a comprehensive and authoritative overview of a century of research on synaptic structure and function culminating in the most recent work. Written by leading experts in the field,
Synapses
will be of interest to a broad range of neuroscientists, including those studying the cellular and molecular mechanisms of synaptic transmission, learning and memory, neuronal plasticity, neurotransmitters, and synaptic morphology. It will also be an essential reference for students and biomedical professionals in all areas of neuroscience.
Contents and contributors:
A Brief History of Synapses and Synaptic Transmission
, W. Maxwell Cowan and Eric R. Kandel
The Structure of Synapses
, Pietro De Camilli, Volker Haucke, Kohji Takei, and Enrico Mugnaini
Physiology of Synaptic Transmission and Short-Term Plasticity
, Wade G. Regehr and Charles F. Stevens
Mechanism and Regulation of Neurotransmitter Release
, Thomas C. Südhof and Richard H. Scheller
Synaptic Vesicle Endocytosis
, Pietro De Camilli, Vladimir I. Slepnev, Oleg Shupliakov, and Lennart Brodin
The Synaptic Cleft and Synaptic Cell Adhesion, Thomas C. Südhof
The Postsynaptic Specialization
, Morgan H.-T. Sheng
Signal Transduction in the Postsynaptic Neuron: Activity-Dependent Regulation of Gene Expression
, Michael E. Greenberg and Edward B. Ziff
Synaptic Plasticity: Diverse Targets and Mechanisms for Regulating Synaptic Efficacy
, Robert C. Malenka and Steven A. Siegelbaum
The Mechanisms and Meaning of Long-Term Synaptic Depression in the Mammalian Brain
, Mark F. Bear and David J. Linden
Synaptic Plasticity and Memory
, Paul D. Grimwood, Stephen J. Martin, and Richard G. M. Morris
Synapse Formation and Maturation
, Ann Marie Craig and Jeff W. Lichtman
Neurotrophins and Refinement of Visual Circuitry
, Edward S. Lein and Carla J. Shatz
Novel Neurotransmitters and Their Neuropsychiatric Relevance
, Solomon H. Snyder and Christopher D. Ferris
Synaptic Variability: New Insights from Reconstructions and Monte Carlo Simulations with Mcell
, Joel R. Stiles, Thomas M. Bartol, Miriam M. Salpeter, Edwin E. Salpeter, and Terrence J. Sejnowski
About the Authors:
W. Maxwell Cowan recently retired as vice president and chief scientific officer at the Howard Hughes Medical Institute (HHMI), Chevy Chase, Maryland. Born and raised in South Africa, Dr. Cowan received his D. Phil from Oxford University and served on the faculty at Oxford before moving to the United States. He was affiliated with Washington University, St.Louis, for 15 years before joining the Salk Institute, where he served as Vice President. In 1986, Dr Cowan returned to Washington University to become Provost and Executive Vice Chancellor. He joined the Howard Hughes Medical Institute in 1988. Dr. Cowan is a Fellow of the Royal Society and a Foreign Associate of the National Academy of Sciences.
Thomas C. Südhof is an HHMI investigator and professor of molecular genetics at the University of Texas Southwestern Medical Center at Dallas. He obtained postdoctoral training first with Victor Whittaker at the Max Planck Institute for Biophysical Chemistry, Göttingen, and then with Michael Brown and Joseph Goldstein in Dallas.
Charles F. Stevens is an HHMI investigator at the Salk Institute for Biological Studies and Adjunct Professor of Pharmacology and of Neuroscience at the University of California, San Diego, School of Medicine. Dr. Stevens is a member of the National Academy of Sciences.