What's more dangerous than a snakebite? A drug-laced marijuana joint that puts the victim into a coma near death! When Dr. Garnet Daniels' niece, Colleen, stumbles into a nest of drug designers and pushers in the Arkansas River Valley, things heat up fast. Colleen, Garnet and Sheriff Curly McCurly follow the trail of the Big One and the designers from a shoe shop in Dardanelle, AR, to the Rio Grande Valley and back to the Ozark and Ouichita Mountains. There Colleen and Garnet come face-to-face with the Big One in a meeting that is more dangerous than a snakebite!