This book constitutes the refereed proceedings of the 12th International Conference on Scalable Uncertainty Management, SUM 2018, which was held in Milan, Italy, in October 2018. The 23 full, 6 short papers and 2 tutorials presented in this volume were carefully reviewed and selected from 37 submissions. The conference is dedicated to the management of large amounts of complex, uncertain, incomplete, or inconsistent information. New approaches have been developed on imprecise probabilities, fuzzy set theory, rough set theory, ordinal uncertainty representations, or even purely qualitative models.