This book addresses the latest approaches to holistic Cyber-Physical System (CPS) resilience in real-world industrial applications. Ensuring the resilience of CPSs requires cross-discipline analysis and involves many challenges and open issues, including how to address evolving cyber-security threats. The book describes emerging paradigms and techniques from two main viewpoints: CPSs’ exposure to new threats, and CPSs’ potential to counteract them. Further, the chapters address topics ranging from risk modeling to threat management and mitigation. The book offers a clearly structured, highly accessible resource for a diverse readership, including graduate students, researchers and industry practitioners who are interested in evaluating and ensuring the resilience of CPSs in both the development and assessment stages.