Protein-protein interaction of Rv0148 with Htdy and its predicted role towards drug resistance in Mycobacterium tuberculosis: Functional role of oxidoreductase Rv0148 in protein-protein interaction and drug resistance in M. tuberculosis

Mycobacterium tuberculosis resides inside host macrophages during infection and adapts to resilient stresses generated by the host immune system. As a response, M. tuberculosis codes for short-chain dehydrogenases/ reductases (SDRs). These SDRs are nicotinamide adenine dinucleotide-reliant oxidoreductases involved in cell homeostasis. The precise function of oxidoreductases in bacteria especially M. tuberculosis were not fully explored. In this study, for the first time, we attempted to predict the functional role of one of the hypothetical oxidoreductase Rv0148 of M. tuberculosis. Overall, the study suggested that Rv0148, though a non-essential gene, is functionally involved in drug resistance and is interconnected with other drug-resistance genes. The absence of Rv0148 displays its prominent role in host immunity.