Professionalism, civility, accountability and "corporate governance" remain critical for public trust. Cross cutting topics and special issues are detailed in this Book. Over the years, controversy has existed regarding FDA decision-making and referred to as "politically charged" such as COVID-19 issues regarding the rush for reliable testing, vaccines and treatment. Morality based determinations also have political implications as illustrated by the Plan B decisions. The question that lingers is whether FDA is truly a science-based agency. Another issue is that of the revolving door impact on post-employment. FDA has post-employment restrictions and there is a statutory application to former employees including what is termed "a cooling off" period. Product classification is a key topic throughout this Book. The intended use rule for tobacco discussed in Book XI, is an excellent example of the complications of product classification. Legal decisions have illustrated that intended use controls in determining product category. That is, the historical decisions of Line Away and Sudden Beauty still provide judicial guidance for regulatory purposes about whether the product is a food, drug, personal care cosmetic product, medical device, dietary supplement or combination product. The question remains whether product categorization should be revisited with a possible amendment of the Food, Drug and Cosmetic Act. The Food, Drug and Cosmetic Act expressly details that FDA cannot regulate the practice of medicine. This exact issue arose in the case of Regenerative Medicine, LLC. The Court of Appeals settled that the product in question in Regenerative Medicine was a drug/biologic. The court rejected the practice of medicine argument set forth by Regenerative Medicine.Counterterrorism remains in the forefront and globalization plays a key role in the regulation of food, drugs, cosmetics, medical devices and biologics. This chapter highlights FDA's role outside of the United States to protect the United States public health from unsafe imported products. Jurisdiction or the authority of FDA to regulate remains imperative. Further the impact of the Foreign Corrupt Practices Act is detailed.What does the future hold in terms of food and drug regulation? How should FDA regulate tobacco products, food, human and veterinary drugs, biologics, medical devices, personal care cosmetic products and dietary supplements? Think about how the regulation of tobacco products fits in the scheme of traditional FDA regulation. Consider how societal mores and culture impact on regulation. The answer is multifaceted and complex. The major focus necessitates a public protection stance to uphold the tenets of the Federal Food, Drug and Cosmetic Act. Finally, this Book concludes with professional practice recommendations.