Are human beings purely material creatures, or is there something else to them, an immaterial part that does some (or all) of the thinking, and might even be able to outlive the death of the body? This book is about how a series of seventeenth-century philosophers tried to answer that question. It begins by looking at the views of Thomas Hobbes, who developed a thoroughly materialist account of the human mind, and later of God as well. This is in obvious contrast to the approach of his contemporary René Descartes. After examining Hobbes's materialism, Stewart Duncan considers the views of three of his English critics: Henry More, Ralph Cudworth, and Margaret Cavendish. Both More and Cudworth thought Hobbes's materialism radically inadequate to explain the workings of the world, while Cavendish developed a distinctive, anti-Hobbesian materialism of her own. The second half of the book focuses on the discussion of materialism in John Locke's Essay concerning Human Understanding, arguing that we can better understand Locke's discussion if we see how and where he is responding to this earlier debate. At crucial points Locke draws on More and Cudworth to argue against Hobbes and other materialists. Nevertheless, Locke did a good deal to reveal how materialism was a genuinely possible view, by showing how one could develop a detailed account of the human mind without presuming it was an immaterial substance.This work probes the thought and debates that originated in the seventeenth-century yet extended far beyond it. And it offers a distinctive, new understanding of Locke's discussion of the human mind.