This book shows how companies can practically implement the advantages of Industry 4.0 and digitalization and also addresses the current challenges with regard to engineering education for Industry 4.0. In this book, we collect the contributions of the 1st Symposium on Industrial Engineering and Automation (ISIEA 2022), which took place from June 21–22, 2022 at the Free University of Bolzano. The contributions cover three basic areas: (1) best practice examples and technical solutions for the implementation of Industry 4.0 in production and logistics, (2) management—oriented approaches for the digital transformation in companies, and (3) addressing Industry 4.0 in engineering education. The book targets different readers. Researchers find approaches to current research topics regarding Industry 4.0. Practitioners find valuable examples for technological implementations as well as management approaches for introducing digitalization. Students and lecturers find hints on how Industry4.0 can be integrated into university teaching.