This book examines the diversity of practice in regional research and its contribution to local, national and global issues. Three themes are advanced here: Place and change, Transition and resilience, and Challenges for the future. Contributors embrace frameworks of co-design and transdisciplinary practice to build communities of practice in response to lived experience in regional contexts. Their work highlights the strategic importance of a regional focus at a time when global connectivity and mobility is increasing and the complexity of ‘wicked’ problems demands more than one approach or solution. Such complex problems require nuanced, and at times ‘bespoke’ methodological approaches to better understand and support not just regional adaptation, resilience and transformation, but to manage all these things at a time when change is everywhere.