Benjamin Rebujio, a neuroscientist and partner at a failing biotech startup, turns to a mob family for funding. When the board finds out, they fire him, sue him for millions, and his family loses their home. With loan sharks closing in, Ben hatches a radical plan: transform himself, his wife Loretta, and their son Reto into lizards and secretly live in the backyard of their foreclosed house. There, they meet Caligula, a mysterious lizard and agent of a simulated universe, sent to return them to human form.