This book shows, first of all, that leadership plays a crucial role in reinventing regions and branching out from an old path to something new in order to create more balanced and sustainable regional development. Second, it maintains that leadership is not a solo but a multi-agent and -level activity and that it needs to be discussed and studied as such. Third, as the book argues, leadership is shaped differently in various institutional and cultural contexts and on different scales. This book explores the ways leadership plays our in regional development context contributing to economically, socially and ecologically balanced sustainable future.