This book constitutes the proceedings of the 15th International Workshop on Knowledge Management and Acquisition for Intelligent Systems, PKAW 2018, held in Nanjing, China, in August 2018. The 15 full papers and 7 short papers included in this volume were carefully reviewed and selected from 51 initial submissions. They cover the methods and tools as well as the applications related to developing a knowledge base, healthcare, financial systems, and intelligent systems.