This issue of Veterinary Clinics: Small Animal Practice focuses on Interventional Radiology and is edited by Dr. Dana Clarke. Article topics include: Perspectives from Human Interventional Radiology; Interventional Equipment and Radiation Safety; IR Management of Tracheal and Bronchial Collapse; IR Management of Portosystemic Shunts and Vascular Malformations; Cardiac Interventions; IR Management of Vascular Obstructions; IR Management of Ureteral and Kidney Diseases; IR Management of Urethral Obstructions; IR Management of Uroliths; and IR Management of Non-Resectable Neoplasia.