This two—volume set constitutes the refereed proceedings of the First EAI International Conference on Intelligent Systems and Machine Learning, ICISML 2022, held in Hyderabad, India, in December 16—17,2022. The 75 full papers presented were carefully reviewed and selected from 209 submissions. The conference focuses on Intelligent Systems and Machine Learning Applications in Health care; Digital Forensic & Network Security; Intelligent Communication Wireless Networks; Internet of Things (IoT) Applications; Social Informatics; and Emerging Applications.