The Life Science industry has been subject to a digital revolution upending all facets of the value chain with data—driven approaches like Gene Therapy, Personalized Medicine, Advanced Cell and Tissue Engineering, Industry 4.0, Artificial Intelligence, Blockchain, Digital Twins, Internet—of—Medical—Things (IoMT) and Software—as—a—Medical—Device (SaMD). Our edited volume offers comprehensive coverage of the digital disruption sweeping through the industry. From drug discovery to manufacturing and life—cycle management, we explore the profound impact of digitalization. Our authors delve into open innovation, sci—fi prototyping, and the digital transformation of medical imaging and healthcare. This volume goes beyond theory to provide practical insights. We present business—oriented case studies, examine M&A topics, venture capital, and other investor perspectives, all with a strong focus on digitalization's role. Furthermore, we explore the cultural and ethical challenges that arise andthe necessary management changes demanded by this digital revolution.