This book constitutes the proceedings of the 14th International Conference on Informatics in Schools: Situation, Evolution and Perspectives, ISSEP 2021, held in Nijmegen, The Netherlands, in November 2020. Due to COVID-19 related travelling restrictions the conference had to be switched to online format. The 12 full papers presented were carefully reviewed and selected from 29 submissions. They are organized in topical sections named: Fostering Computational Thinking, Programming Education, Advancing Computing Education, and Teachers’ Professional Development.