This book constitutes the refereed proceedings of the 10th International ICT Innovations Conference, ICT Innovations 2018, held in Ohrid, Macedonia, in September 2018.The 21 full papers presented were carefully reviewed and selected from 81 submissions. They cover the following topics:sensor applications and deployments, embedded and cyber-physical systems, robotics, network architectures, cloud computing, software infrastructure, software creation and management, models of computation, computational complexity and cryptography, design and analysis of algorithms, mathematical optimization, probability and statistics, data management systems, data mining, human computer interaction (HCI), artificial intelligence, machine learning, life and medical sciences, health care information systems, bioinformatics.