This handbook addresses the radiation biology, physics, nuclear medicine, and imaging for radioembolization, which is now the preferred treatment for both primary and secondary liver cancer. It highlights the use of Yttrium-90 (90Y) microspheres in addition to discussing aspects related to interventional radiology. The contents reflect new on-label hepatic treatment indications, both in the US and worldwide, as well as dose-response relationships associated with radioembolization and the utility of adjuvant radioembolization and systemic chemotherapy. The authors address the need for an integrated strategy and guidelines for a multidisciplinary team for providing cutting-edge patient-specific radioembolization treatment. It also showcases the important role of imaging in the development of treatment and management strategies. This handbook includes numerous illustrative images and patient-based examples.