Handbook of Hematology Research: Hemorheology, Hemophilia and Blood Coagulation in Bloomington, MN

Hematology is the branch of medicine that deals with diseases of the blood and blood-forming organs. Hemophilia is one of the most important diseases of hematology research. Medically, the classical treatment of hemophilia is transfusion therapy, which has been widely used for years. However, the transfusion can bring several complications for hemophiliac patients, such as the onset of blood borne infectious diseases. This book discusses such diseases, as well as the new trend in blood product safety management. Until present, the new modality of gene therapy is the hope for successfully treating hemophilia. The authors of this book briefly review and discuss this new hemophilia treatment. In addition to examining the etiology, pathogenesis and treatment of hemophilia, the factors involved in the activation of blood coagulation are examined as well. Other chapters in this book explore the immune responses and induction of immune tolerance to FVIII/FIX in hemophilia gene transfer, the haemostatic changes in complicated pregnancy states like preeclampsia and pregnancy-induced hypertension, a review of the new routine parameters for diagnosis of the early phases of pathologic disseminated intravascular coagulation (PDIC), and the quantitative and qualitative congenital plasminogen defects of the fibrinolytic system.