Full Mouth Rehabilitation is a comprehensive dental approach aimed at restoring the function, aesthetics, and health of the entire dentition. It is particularly beneficial for patients with extensive dental issues, including tooth wear, loss, or occlusal discrepancies. The masticatory system's anatomy and physiology comprising the maxilla, mandible, temporomandibular joints, muscles of mastication, and neuromuscular coordination are fundamental to understanding full mouth rehabilitation. Proper function and harmony among these components are crucial for successful rehabilitation. Restoring the vertical dimension is critical, as its loss can affect facial aesthetics and function. Mouth preparation may involve selective grinding and establishing occlusal schemes. Mounting models using facebow transfers and setting condylar guidance are essential steps in replicating mandibular movements. Success depends on precise execution and patient compliance, addressing these challenges necessitates treatment planning, effective abutment preparation, regular follow-ups, patient education, expectation management, and collaborative efforts among specialists.