All children deserve access to the conditions and opportunities needed to thrive, including unbiased accessible healthcare and high-quality learning opportunities; safe, toxin-free communities and stable housing; access to nutritious meals; and secure, warm, available, and loving caregivers. Historic and contemporary injustices in US society have created inequities in opportunity and access to resources for Black, Latine, Asian, American Indian and Alaska Native, and other children of color, children with disabilities, children in poverty, and other marginalized children; these have contributed to stark disparities across child development outcomes. This Element overviews inequities in economic, educational, and health systems through historical and contemporary perspectives and describes how these inequities impact children and families. Solutions to address these inequities are considered for a fairer US society, starting with its youngest residents, where all families have what they need to thrive. This title is also available as Open Access on Cambridge Core.