This book constitutes the refereed post-conference proceedings of the 25th International Conference on Distributed and Computer and Communication Networks, DCCN 2022, held in Moscow, Russia, in September 26–29, 2022. The 31 revised full papers and 2 revised short papers were carefully reviewed and selected from 130 submissions. The papers cover the following topics: computer and communication networks; analytical modeling of distributed systems; and distributed systems applications.