Design and Analysis of DNA Microarray Investigations / Edition 1

Many laboratories are not equipped to effectively design and analyze studies that take advantage of the promise of microarrays. Many of the software packages available to biologists were developed without involvement of statisticians experienced in such studies and contain tools that may not be optimal for particular applications. This book provides a sound preparation for designing microarray studies that have clear objectives, and for selecting analysis tools and strategies that provide clear and valid answers. The book offers an in-depth understanding of the design and analysis of experiments utilizing microarrays and should benefit scientists regardless of what software packages they prefer. In order to provide all readers with hands-on experience in data analysis, it includes an appendix tutorial on the use of BRB-ArrayTools and step-by-step analyses of several major datasets using this software, which is freely available from the National Cancer Institute for noncommercial use. The authors are current or former members of the Biometric Research Branch at the National Cancer Institute. They have collaborated on major biomedical studies utilizing microarrays and in the development of statistical methodology for the design and analysis of microarray investigations. Dr. Simon, chief of the branch, is also the architect of BRB-ArrayTools.