This book provides a comprehensive overview of recent novel coronavirus (SARS—CoV—2) infection, their biology and associated challenges for their treatment and prevention of novel Coronavirus Disease 2019 (COVID—19). Discussing various aspects of COVID—19 infection, including global epidemiology, genome organization, immunopathogenesis, transmission cycle, diagnosis, treatment, prevention, and control strategies, it highlights host—pathogen interactions, host immune response, and pathogen immune invasion strategies toward developing an immune intervention or preventive vaccine for COVID—19. An understanding of the topics covered in the book is imperative in the context of designing strategies to protect the human race from further losses and harm due to SARS—CoV—2 infection causing COVID—19.