This book examines the role of chemokines in mediating human disease. Specifically, this book presents an overview of the two chemokine supergene families and their receptors. The role of these mediators in arthritis, skin disease and renal disease is evaluated. Focusing on lung diseases, the role of these factors in the neutrophil recruitment in the lung and in pneumonia is presented, as well as a summary of the role of these mediators in granulomatous disease. Of interest to scientists in the field of vascular biology are the chapters on ischemia/reperfusion injury, and angiogenesis.