This book constitutes selected and revised papers of the First International Conference on Artificial Intelligence and Sustainable Computing for Smart City, AIS2C2 2021, held in Greater Noida, India, in March 2021. Due to the COVID-19 pandemic the conference was held online. The 17 full papers and 3 short papers included were thoroughly reviewed and selected from 204 submissions. They are organized in the following topical sections: ​sentimental and emotions analysis for smart cities; smart specialization strategies for smart cities; security in smart cities; advances applications for future smart cities; healthcare in smart cities; machine learning applications in smart cities.