Having survived childhood and deadly adventures in "Annie's World: Jake's Legacy", Annie Henderson has blossomed into a teenaged warrior and savior genetically superior to most humans. "In Annie's World 2: New Beginnings", she cannot allow cannibals in Old Dallas to go unchecked, nor can she let a child trafficking operation go unchallenged. Anyone of the dangers she encounters might get her killed. Annie and her newfound friends face the most dangerous quest of her young life.