Antarctic and Southern Ocean scientific research has produced a wide array of important and exciting scientific advances. Spanning oceanography to tectonics, microbiology to astrophysics, the extreme Antarctic environment provides unique opportunities to expand our knowledge about how our planet works and even the very origins of the universe. Research on the Southern Ocean and the Antarctic ice sheets is becoming increasingly urgent not only for understanding the future of the region but also its interconnections with and impacts on many other parts of the globe. The U.S. National Science Foundation (NSF) provides U.S. researchers with broad access to the continent and its surrounding ocean. A Strategic Vision for NSF Investments in Antarctic and Southern Ocean Research identifies priorities and strategic steps forward for Antarctic research and observations for the next decade. This survey presents a decadal vision for strategic investments in compelling research and the infrastructure most critical for supporting this research. This report makes recommendations for high-priority, larger-scale, community-driven research initiatives that address questions poised for significant advance with the next decades. This report also outlines a roadmap through which the vision and these priorities can be met.