This book constitutes the proceedings of the 15th Ada-Europe International Conference on Reliable Software Technologies, Ada-Europe 2010, held in Valencia, Spain, on June 14-18, 2010. The 17 papers presented were carefully reviewed and selected from 40 submissions. Topics of interest to the conference are software dependability, critical, real-time and distributed systems, and language technology, all under the more general heading of Reliable Software Technologies.